An emerging role of the 5' termini of mature tRNAs in human diseases: Current situation and prospects.
Biochim Biophys Acta Mol Basis Dis
; 1868(2): 166314, 2022 02 01.
Article
em En
| MEDLINE
| ID: mdl-34863896
ABSTRACT
The fundamental biological roles of a class of small noncoding RNAs (sncRNAs), derived from mature tRNAs or pre-tRNAs, in human diseases have received increasing attention in recent years. These ncRNAs are called tRNA-derived fragments (tRFs) or tRNA-derived small RNAs (tsRNAs). tRFs mainly include tRF-1, tRF-5, tRF-3 and tRNA halves (tiRNAs or tRHs), which are produced by enzyme-specific cleavage of tRNAs. Here, we classify tRF-5 and 5' tiRNAs into the same category 5'-tRFs and review the biological functions and regulatory mechanisms of 5'-tRFs in cancer and other diseases (metabolic diseases, neurodegenerative diseases, pathological stress injury and virus infection) to provide a new theoretical basis for the diagnosis and treatment of diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
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RNA de Transferência
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Regulação Neoplásica da Expressão Gênica
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Doenças Neurodegenerativas
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Doenças Metabólicas
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biochim Biophys Acta Mol Basis Dis
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China