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Development of MDS-Based Predication Model for COPD Severity in Nursing Home Residents.
Blaylock, Barbara; Niu, Xiaoli; Davidson, H Edward; Gravenstein, Stefan; DePue, Ronald; Williams, G Rhys; Steinberg, Karl E.
Afiliação
  • Blaylock B; Blaylock Health Economics LLC, Los Angeles, CA, USA.
  • Niu X; Health Economics and Outcomes Research, Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.
  • Davidson HE; Insight Therapeutics, LLC, Norfolk, VA, USA.
  • Gravenstein S; Department of Health Services, Policy and Practice, Center for Gerontology and Health Care Research, Brown University, Providence, RI, USA.
  • DePue R; Health Economics and Outcomes Research, Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.
  • Williams GR; Health Economics and Outcomes Research, Sunovion Pharmaceuticals Inc., Marlborough, MA, USA.
  • Steinberg KE; Shiley Institute for Palliative Care, The California State University, San Marcos, CA, USA.
Ann Pharmacother ; 56(8): 878-887, 2022 08.
Article em En | MEDLINE | ID: mdl-34963317
BACKGROUND: Assessing chronic obstructive pulmonary disease (COPD) severity is challenging in nursing home (NH) residents due to incomplete symptom assessments and exacerbation history. OBJECTIVE: The objective of this study was to predict COPD severity in NH residents using the Minimum Data Set (MDS), a clinical assessment of functional capabilities and health needs. METHODS: A cohort analysis of prospectively collected longitudinal data was conducted. Residents from geographically varied Medicare-certified NHs with age ≥60 years, COPD diagnosis, and ≥6 months NH residence at enrollment were included. Residents with severe cognitive impairment were excluded. Demographic characteristics, medical history, and MDS variables were extracted from medical records. The care provider-completed COPD Assessment Test (CAT) and COPD exacerbation history were used to categorize residents by Global Initiative for Chronic Lung Disease (GOLD) A to D groups. Multivariate multinomial logit models mapped the MDS to GOLD A to D groups with stepwise selection of variables. RESULTS: Nursing home residents (N = 175) were 64% women and had a mean age of 77.9 years. Among residents, GOLD B was most common (A = 13.1%; B = 44.0%; C = 5.7%; D = 37.1%). Any long-acting bronchodilator (LABD) use and any dyspnea were significant predictors of GOLD A to D groups. The predicted MDS-GOLD group (A = 6.9%; B = 52.6%; C = 4.6%; D = 36.0%) showed good model fit (correctly predicted = 60.6%). Nursing home residents may underuse group-recommended LABD treatment (no LABD: B = 53.2%; C = 80.0%; D = 40.0%). CONCLUSION AND RELEVANCE: The MDS, completed routinely for US NH residents, could potentially be used to estimate COPD severity. Predicted COPD severity with additional validation could provide a map to evidence-based treatment guidelines and may help to individualize treatment pathways for NH residents.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Casas de Saúde Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Ann Pharmacother Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Casas de Saúde Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do norte Idioma: En Revista: Ann Pharmacother Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos