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Laponite-Based Nanomaterials for Drug Delivery.
Kiaee, Gita; Dimitrakakis, Nikolaos; Sharifzadeh, Shabnam; Kim, Han-Jun; Avery, Reginald K; Moghaddam, Kamyar Mollozadeh; Haghniaz, Reihaneh; Yalcintas, Ezgi Pinar; Barros, Natan Roberto de; Karamikamkar, Solmaz; Libanori, Alberto; Khademhosseini, Ali; Khoshakhlagh, Parastoo.
Afiliação
  • Kiaee G; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
  • Dimitrakakis N; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
  • Sharifzadeh S; Dana-Farber Cancer Institute, Boston, MA, 02115, USA.
  • Kim HJ; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Avery RK; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
  • Moghaddam KM; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
  • Haghniaz R; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Yalcintas EP; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Barros NR; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Karamikamkar S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Libanori A; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
  • Khademhosseini A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90024, USA.
  • Khoshakhlagh P; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.
Adv Healthc Mater ; 11(7): e2102054, 2022 04.
Article em En | MEDLINE | ID: mdl-34990081
ABSTRACT
Laponite is a clay-based material composed of synthetic disk-shaped crystalline nanoparticles with highly ionic, large surface area. These characteristics enable the intercalation and dissolution of biomolecules in Laponite-based drug delivery systems. Furthermore, Laponite's innate physicochemical properties and architecture enable the development of tunable pH-responsive drug delivery systems. Laponite's coagulation capacity and cation exchangeability determine its exchange capabilities, drug encapsulation efficiency, and release profile. These parameters are exploited to design highly controlled and efficacious drug delivery platforms for sustained drug release. In this review, they provide an overview of how to design efficient delivery of therapeutics by leveraging the properties and specific interactions of various Laponite-polymer composites and drug moieties.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanoestruturas / Nanopartículas Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanoestruturas / Nanopartículas Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos