Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice.

Guo, Zhen; Tuo, Hu; Tang, Nan; Liu, Fang-Yuan; Ma, Shu-Qing; An, Peng; Yang, Dan; Wang, Min-Yu; Fan, Di; Yang, Zheng; Tang, Qi-Zhu

Guo, Zhen; Tuo, Hu; Tang, Nan; Liu, Fang-Yuan; Ma, Shu-Qing; An, Peng; Yang, Dan; Wang, Min-Yu; Fan, Di; Yang, Zheng; Tang, Qi-Zhu.

Afiliação

Guo Z; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China.
Tuo H; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, RP China.
Tang N; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China.
Liu FY; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, RP China.
Ma SQ; The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian 223800, RP China.
An P; People's Hospital affiliated to Nanjing Drama Tower Hospital Group, Suqian 223800, RP China.
Yang D; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China.
Wang MY; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, RP China.
Fan D; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China.
Yang Z; Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, RP China.
Tang QZ; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China.

Int J Biol Sci ; 18(2): 826-840, 2022.

Article em En | MEDLINE | ID: mdl-35002528

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Diabetes Mellitus Experimental/complicações; Cardiomiopatias Diabéticas/genética; Mucolipidoses/complicações; Neuraminidase/genética; Animais; Animais Recém-Nascidos; Apoptose; Diabetes Mellitus Experimental/genética; Fibrose; Inflamação; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mucolipidoses/genética; Miocárdio/patologia; Estresse Oxidativo; Ratos; Transdução de Sinais; Sirtuína 3/metabolismo; Estreptozocina

Palavras-chave

AMPKα; Diabetic cardiomyopathy; LKB1; Neuraminidase 1; SIRT3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Proteínas Quinases Ativadas por AMP / Cardiomiopatias Diabéticas / Mucolipidoses / Neuraminidase Limite: Animals Idioma: En Revista: Int J Biol Sci Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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