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Skeletal muscle derived Musclin protects the heart during pathological overload.
Szaroszyk, Malgorzata; Kattih, Badder; Martin-Garrido, Abel; Trogisch, Felix A; Dittrich, Gesine M; Grund, Andrea; Abouissa, Aya; Derlin, Katja; Meier, Martin; Holler, Tim; Korf-Klingebiel, Mortimer; Völker, Katharina; Garfias Macedo, Tania; Pablo Tortola, Cristina; Boschmann, Michael; Huang, Nora; Froese, Natali; Zwadlo, Carolin; Malek Mohammadi, Mona; Luo, Xiaojing; Wagner, Michael; Cordero, Julio; Geffers, Robert; Batkai, Sandor; Thum, Thomas; Bork, Nadja; Nikolaev, Viacheslav O; Müller, Oliver J; Katus, Hugo A; El-Armouche, Ali; Kraft, Theresia; Springer, Jochen; Dobreva, Gergana; Wollert, Kai C; Fielitz, Jens; von Haehling, Stephan; Kuhn, Michaela; Bauersachs, Johann; Heineke, Joerg.
Afiliação
  • Szaroszyk M; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Kattih B; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. Badder.Kattih@kgu.de.
  • Martin-Garrido A; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Badder.Kattih@kgu.de.
  • Trogisch FA; Department of Medicine, Cardiology, Goethe University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. Badder.Kattih@kgu.de.
  • Dittrich GM; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Grund A; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Abouissa A; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Derlin K; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Meier M; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Holler T; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Korf-Klingebiel M; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Völker K; Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
  • Garfias Macedo T; Central Animal Facility, Hannover Medical School, Hannover, Germany.
  • Pablo Tortola C; Institute of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
  • Boschmann M; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Huang N; Institute of Physiology and Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany.
  • Froese N; Department of Cardiology and Pneumology, University of Göttingen Medical Center, DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.
  • Zwadlo C; Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Malek Mohammadi M; Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Luo X; Experimental and Clinical Research Center (ECRC), Charité-University Medical Center Berlin, Max Delbrück Center (MDC) for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Wagner M; Department of Cardiology, Heart Center Brandenburg and Medical University Brandenburg (MHB), Bernau, Germany.
  • Cordero J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Geffers R; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
  • Batkai S; Department for Cardiovascular Physiology, European Center of Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Thum T; Institute of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany.
  • Bork N; Institute of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany.
  • Nikolaev VO; Department of Electrophysiology, Heart Center, Dresden University of Technology, Dresden, Germany.
  • Müller OJ; Anatomy and Developmental Biology, ECAS, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Katus HA; RG Genome Analytics, Helmholtz Center for Infection Research, Braunschweig, Germany.
  • El-Armouche A; Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
  • Kraft T; Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.
  • Springer J; National Heart and Lung Institute, Imperial College London, London, UK.
  • Dobreva G; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany.
  • Wollert KC; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fielitz J; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • von Haehling S; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Kuhn M; DZHK, partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.
  • Bauersachs J; Department of Cardiology, Angiology, and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.
  • Heineke J; DZHK, partner site Heidelberg/Mannheim, Heidelberg, Germany.
Nat Commun ; 13(1): 149, 2022 01 10.
Article em En | MEDLINE | ID: mdl-35013221
Assuntos
Caquexia/genética; Fibrose Endomiocárdica/genética; Insuficiência Cardíaca/genética; Proteínas Musculares/genética; Músculo Esquelético/metabolismo; Atrofia Muscular/genética; Fatores de Transcrição/genética; 2',3'-Nucleotídeo Cíclico 3'-Fosfodiesterase/genética; 2',3'-Nucleotídeo Cíclico 3'-Fosfodiesterase/metabolismo; Idoso; Idoso de 80 Anos ou mais; Animais; Caquexia/metabolismo; Caquexia/fisiopatologia; Caquexia/prevenção & controle; Estudos de Casos e Controles; Proteínas Quinases Dependentes de AMP Cíclico/genética; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Proteínas Quinases Dependentes de GMP Cíclico/genética; Proteínas Quinases Dependentes de GMP Cíclico/metabolismo; Modelos Animais de Doenças; Fibrose Endomiocárdica/metabolismo; Fibrose Endomiocárdica/fisiopatologia; Fibrose Endomiocárdica/prevenção & controle; Feminino; Regulação da Expressão Gênica; Insuficiência Cardíaca/metabolismo; Insuficiência Cardíaca/fisiopatologia; Insuficiência Cardíaca/prevenção & controle; Testes de Função Cardíaca; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas Musculares/agonistas; Proteínas Musculares/antagonistas & inibidores; Proteínas Musculares/deficiência; Atrofia Muscular/metabolismo; Atrofia Muscular/fisiopatologia; Atrofia Muscular/prevenção & controle; Miocárdio/metabolismo; Miocárdio/patologia; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Transdução de Sinais; Fatores de Transcrição/agonistas; Fatores de Transcrição/antagonistas & inibidores; Fatores de Transcrição/deficiência
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Caquexia / Atrofia Muscular / Músculo Esquelético / Fibrose Endomiocárdica / Insuficiência Cardíaca / Proteínas Musculares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Caquexia / Atrofia Muscular / Músculo Esquelético / Fibrose Endomiocárdica / Insuficiência Cardíaca / Proteínas Musculares Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha