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The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2.
Dayalan Naidu, Sharadha; Suzuki, Takafumi; Dikovskaya, Dina; Knatko, Elena V; Higgins, Maureen; Sato, Miu; Novak, Miroslav; Villegas, José A; Moore, Terry W; Yamamoto, Masayuki; Dinkova-Kostova, Albena T.
Afiliação
  • Dayalan Naidu S; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
  • Suzuki T; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Dikovskaya D; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
  • Knatko EV; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
  • Higgins M; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
  • Sato M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Novak M; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
  • Villegas JA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Moore TW; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Dinkova-Kostova AT; Division of Cellular Medicine, School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, James Arnott Drive, Dundee, Scotland DD1 9SY, UK.
iScience ; 25(1): 103703, 2022 Jan 21.
Article em En | MEDLINE | ID: mdl-35036882
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido