Structural insights into the antifungal drug target guanosine monophosphate synthase from Aspergillus fumigatus.

Nguyen, Stephanie; Jovcevski, Blagojce; Pukala, Tara L; Bruning, John B

Nguyen, Stephanie; Jovcevski, Blagojce; Pukala, Tara L; Bruning, John B.

Afiliação

Nguyen S; Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Jovcevski B; School of Physical Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Pukala TL; School of Physical Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Bruning JB; Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.

Acta Crystallogr D Struct Biol ; 78(Pt 2): 248-259, 2022 Feb 01.

Article em En | MEDLINE | ID: mdl-35102890

Assuntos

Antifúngicos; Aspergillus fumigatus; Antifúngicos/metabolismo; Antifúngicos/farmacologia; Aspergillus fumigatus/genética; Aspergillus fumigatus/metabolismo; Candida albicans/metabolismo; Carbono-Nitrogênio Ligases; Proteínas Fúngicas/metabolismo; Guanosina Monofosfato/metabolismo; Humanos

Palavras-chave

Aspergillus fumigatus; antifungal targets; guanosine monophosphate synthase; nucleotide biosynthesis; purine biosynthesis; structural biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus fumigatus / Antifúngicos Limite: Humans Idioma: En Revista: Acta Crystallogr D Struct Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália

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