[Cerebrospinal Fluid ß2-Microglobulin for Prognostic Evaluation of Patients with Central Nervous System Infiltration in Acute Lymphoblastic Leukemia].

ABSTRACT

OBJECTIVE: To investigate the prognostic value of serum and cerebrospinal fluid ß2-microglobulin (ß2-MG) in acute lymphoblastic leukemia (ALL) with central nervous system invasion after chemotherapy. METHODS: 40 patients with leukemia who had been confirmed to have central nervous system infiltration were selected for treatment at the Second Affiliated Hospital of Chongqing Medical University from January 2015 to May 2017, and the serum levels of ß2-MG and CSF-ß2MG were dynamically monitored and performed statistical analysis. RESULTS: After chemotherapy, the changes in serum ß2-MG were not statistically significant (P>0.05); the absolute level of CSF-ß2MG and the percentage of relative baseline changes were statistically different in different clinical outcome groups(P<0.05), and the decreasing CSF-ß2MG levels suggest a better prognosis, with cut-off values of 1.505 and -25%, respectively. CONCLUSION: The best cut-off point may be a predictor of complete remission; the reduction of the absolute and relative levels of CSF-ß2MG can suggest a good prognosis for patients.