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CD4, CD8 and natural killer cells are depressed in patients with alopecia areata: their association with disease activity.
Younes, Abdel-Khalek; Hammad, Refaat; Othman, Mona; Sobhy, Ali.
Afiliação
  • Younes AK; Dermatology, Andrology and STIs Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
  • Hammad R; Dermatology, Andrology and STIs Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
  • Othman M; Dermatology, Andrology and STIs Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt. monahassan3333@azhar.edu.eg.
  • Sobhy A; Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
BMC Immunol ; 23(1): 13, 2022 03 17.
Article em En | MEDLINE | ID: mdl-35300587
ABSTRACT

BACKGROUND:

Alopecia areata (AA) is a common inflammatory disorder targeting the hair follicles leading to non-scaring hair loss. The pathogenesis of AA is still unclear, despite the accumulating evidence of the immune-mediated nature of this disease. So, in this study, we aimed to assess the level of CD4 T cells, CD8 T cells and natural killer (NK) cells in the peripheral blood of patients with active AA and control subjects, and to evaluate the association between the level of those cells and the duration of disease in different subtypes of AA.

RESULTS:

Fifty female patients and 50 age- and sex-matched healthy controls were enrolled in this case control study. CBC analysis and the level of CD4, CD8 T cells and NK cells were evaluated during the active stage of the disease. We found that CD4, CD8 T cells and NK cells proportion was significantly lower (P < 0.05) in patients with active stage AA compared with healthy subjects, however, the ratio of CD4CD8 T cells was significantly higher in patients than control subjects. The level of CD4, CD8 T cells CD56 bright CD16- % NK cells were positively correlated with the disease duration.

CONCLUSION:

Active stage of AA disease is associated with a reduction of the circulating CD4, CD8 T cells and NK cells and an increase in CD4/CD8 T cells ratio, however, the level of those cells were higher with prolonged disease duration. Our findings confirm that immune mechanisms are involved in the pathogenesis of AA.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alopecia em Áreas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: BMC Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alopecia em Áreas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: BMC Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Egito