A Genome-Wide CRISPR Activation Screen Identifies PRRX2 as a Regulator of Enzalutamide Resistance in Prostate Cancer.

Rodríguez, Yara; Unno, Kenji; Truica, Mihai I; Chalmers, Zachary R; Yoo, Young A; Vatapalli, Rajita; Sagar, Vinay; Yu, Jindan; Lysy, Barbara; Hussain, Maha; Han, Huiying; Abdulkadir, Sarki A

Rodríguez, Yara; Unno, Kenji; Truica, Mihai I; Chalmers, Zachary R; Yoo, Young A; Vatapalli, Rajita; Sagar, Vinay; Yu, Jindan; Lysy, Barbara; Hussain, Maha; Han, Huiying; Abdulkadir, Sarki A.

Afiliação

Rodríguez Y; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Unno K; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Truica MI; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Chalmers ZR; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Yoo YA; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Vatapalli R; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Sagar V; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Yu J; Department of Medicine, Division of Hematology/Oncology, Department of Biochemistry and Molecular Genetics, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Lysy B; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Hussain M; The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Han H; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Abdulkadir SA; Department of Urology, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Cancer Res ; 82(11): 2110-2123, 2022 06 06.

Article em En | MEDLINE | ID: mdl-35405009

Assuntos

Antineoplásicos; Neoplasias de Próstata Resistentes à Castração; Antagonistas de Receptores de Andrógenos/farmacologia; Antineoplásicos/farmacologia; Benzamidas; Linhagem Celular Tumoral; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; Resistencia a Medicamentos Antineoplásicos/genética; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Humanos; Masculino; Nitrilas/uso terapêutico; Feniltioidantoína; Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico; Neoplasias de Próstata Resistentes à Castração/genética; Neoplasias de Próstata Resistentes à Castração/patologia; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Receptores Androgênicos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração / Antineoplásicos Limite: Humans / Male Idioma: En Revista: Cancer Res Ano de publicação: 2022 Tipo de documento: Article

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