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How previous treatment changes the metabolomic profile in patients with metastatic breast cancer.
Nees, Juliane; Schafferer, Simon; Yuan, Baowen; Tang, Quiqong; Scheffler, Matthias; Hartkopf, Andreas; Golatta, Michael; Schneeweiß, Andreas; Burwinkel, Barbara; Wallwiener, Markus.
Afiliação
  • Nees J; Department of Gynecology and Obstetrics, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Juliane.Nees@med.uni-heidelberg.de.
  • Schafferer S; BIOCRATES Life Sciences AG, 6020, Innsbruck, Austria.
  • Yuan B; Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, 69120, Heidelberg, Germany.
  • Tang Q; Division of Molecular Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Scheffler M; Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, University of Heidelberg, 69120, Heidelberg, Germany.
  • Hartkopf A; Division of Molecular Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Golatta M; BIOCRATES Life Sciences AG, 6020, Innsbruck, Austria.
  • Schneeweiß A; Department of Women's Health, University of Tübingen, 72076, Tübingen, Germany.
  • Burwinkel B; Department of Gynecology and Obstetrics, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Wallwiener M; National Center for Tumor Diseases (NCT), 69120, Heidelberg, Germany.
Arch Gynecol Obstet ; 306(6): 2115-2122, 2022 12.
Article em En | MEDLINE | ID: mdl-35467121
PURPOSE: Metabolites are in the spotlight of attention as promising novel breast cancer biomarkers. However, no study has been conducted concerning changes in the metabolomics profile of metastatic breast cancer patients according to previous therapy. METHODS: We performed a retrospective, single-center, nonrandomized, partially blinded, treatment-based study. Metastatic breast cancer (MBC) patients were enrolled between 03/2010 and 09/2016 at the beginning of a new systemic therapy. The endogenous metabolites in the plasma samples were analyzed using the AbsoluteIDQ® p180 Kit (Biocrates Life Sciences AG, Innsbruck) a targeted, quality and quantitative-controlled metabolomics approach. The statistical analysis was performed using R package, version 3.3.1. ANOVA was used to statistically assess age differences within groups. Furthermore, we analyzed the CTC status of the patients using the CellSearch™ assay. RESULTS: We included 178 patients in our study. Upon dividing the study population according to therapy before study inclusion, we found the following: 4 patients had received no therapy, 165 chemotherapy, and 135 anti-hormonal therapy, 30 with anti-Her2 therapy and 38 had received treatment with bevacizumab. Two metabolites were found to be significantly different, depending on the further therapy of the patients: methionine and serine. Whereas methionine levels were higher in the blood of patients who received an anti-Her2-therapy, serine was lower in patients with endocrine therapy only. CONCLUSION: We identified two metabolites for which concentrations differed significantly depending on previous therapies, which could help to choose the next therapy in patients who have already received numerous different treatments.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Células Neoplásicas Circulantes Tipo de estudo: Observational_studies Limite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Células Neoplásicas Circulantes Tipo de estudo: Observational_studies Limite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha