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Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma.
Karavyraki, Marilena; Porter, Richard K.
Afiliação
  • Karavyraki M; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Science Institute (TBSI), Pearse Street, Dublin, D02 R590, Ireland.
  • Porter RK; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Science Institute (TBSI), Pearse Street, Dublin, D02 R590, Ireland. rkporter@tcd.ie.
Med Oncol ; 39(5): 60, 2022 Apr 29.
Article em En | MEDLINE | ID: mdl-35484352
In an endeavour to understand metastasis from oral squamous cell carcinomas, we characterised the metastatic potential of a human tongue derived cell line (SCC-4 cells) and compared this phenotype to pre-cancerous dysplastic oral keratinocyte (DOK) cells derived from human tongue and primary gingival keratinocytes (PGK). We demonstrate that SCC-4 cells constitutively synthesize and release significant amounts of IL-6, a process that is enhanced by the addition of the TLR2/TLR6 agonist, Pam2CSK4. The expression of TLR2/6 and IL-6Ra/gp130 receptors was also confirmed in SCC-4 cells. Cancerous SCC-4 human tongue cells also have a classic EMT profile, unlike precancerous human tongue DOK cells. We also established that IL-6 is driving anoikis resistance in an autocrine fashion and that anti-IL-6 neutralising antibodies, anti-IL-6 receptor antibodies and anti-TLR2 receptor antibodies inhibit anoikis resistance in cancerous SCC-4 human tongue cells. The data suggest a promising role for anti-IL-6 receptor antibody and anti-TLR2 receptor antibody treatment for oral cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Neoplasias da Língua / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irlanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Neoplasias da Língua / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Limite: Humans Idioma: En Revista: Med Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Irlanda