Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells via S1PR3 by Ligand-Independent Notch Activation.

Hirata, Naoya; Yamada, Shigeru; Yanagida, Shota; Ono, Atsushi; Yasuhiko, Yukuto; Kanda, Yasunari

Hirata, Naoya; Yamada, Shigeru; Yanagida, Shota; Ono, Atsushi; Yasuhiko, Yukuto; Kanda, Yasunari.

Afiliação

Hirata N; Division of Pharmacology, National Institute of Health Sciences.
Yamada S; Division of Pharmacology, National Institute of Health Sciences.
Yanagida S; Division of Pharmacology, National Institute of Health Sciences.
Ono A; Division of Pharmaceutical Sciences, Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Yasuhiko Y; Division of Pharmaceutical Sciences, Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University.
Kanda Y; Division of Pharmacology, National Institute of Health Sciences.

Biol Pharm Bull ; 45(5): 649-658, 2022.

Article em En | MEDLINE | ID: mdl-35491169

Assuntos

Neoplasias; Fator de Crescimento Transformador beta; Ligantes; Células-Tronco Neoplásicas; Fosforilação; Transdução de Sinais; Fator de Crescimento Transformador beta/farmacologia

Palavras-chave

ALK5; Notch; Transforming Growth Factor-ß (TGFß); cancer stem cell; sphingosine kinase 1 (SphK1); sphingosine-1-phosphate (S1P)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Neoplasias Tipo de estudo: Prognostic_studies Idioma: En Revista: Biol Pharm Bull Assunto da revista: BIOQUIMICA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article

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