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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Govender, Preshendren; Müller, Rudolf; Singh, Kawaljit; Reddy, Virsinha; Eyermann, Charles J; Fienberg, Stephen; Ghorpade, Sandeep R; Koekemoer, Lizbé; Myrick, Alissa; Schnappinger, Dirk; Engelhart, Curtis; Meshanni, Jaclynn; Byl, Jo Ann W; Osheroff, Neil; Singh, Vinayak; Chibale, Kelly; Basarab, Gregory S.
Afiliação
  • Govender P; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Müller R; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Singh K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Reddy V; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Eyermann CJ; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Fienberg S; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Ghorpade SR; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Koekemoer L; Drug Discovery and Development Centre (H3D) South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Myrick A; Drug Discovery and Development Centre (H3D) South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
  • Engelhart C; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
  • Meshanni J; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, United States.
  • Byl JAW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Osheroff N; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Singh V; Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
  • Chibale K; VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, United States.
  • Basarab GS; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
J Med Chem ; 65(9): 6903-6925, 2022 05 12.
Article em En | MEDLINE | ID: mdl-35500229
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Topoisomerase II / Mycobacterium tuberculosis Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Topoisomerase II / Mycobacterium tuberculosis Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul