COVID-19 susceptibility and clinical outcomes in autoimmune inflammatory rheumatic diseases (AIRDs): a systematic review and meta-analysis.
Eur Rev Med Pharmacol Sci
; 26(10): 3760-3770, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35647859
ABSTRACT
OBJECTIVE:
This meta-analysis aims to assess the susceptibility to and clinical outcomes of COVID-19 in autoimmune inflammatory rheumatic disease (AIRD) and following AIRD drug use. MATERIALS ANDMETHODS:
We included observational and case-controlled studies assessing susceptibility and clinical outcomes of COVID-19 in patients with AIRD as well as the clinical outcomes of COVID-19 with or without use of steroids and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).RESULTS:
Meta-analysis including three studies showed that patients with AIRD are not more susceptible to COVID-19 compared to patients without AIRD or the general population (OR 1.11, 95% CI 0.58 to 2.14). Incidence of severe outcomes of COVID-19 (OR 1.34, 95% CI 0.76 to 2.35) and COVID-19 related death (OR 1.21, 95% CI 0.68 to 2.16) also did not show significant difference. The clinical outcomes of COVID-19 among AIRD patients with and without csDMARD or steroid showed that both use of steroid (OR 1.69, 95% CI 0.96 to 2.98) or csDMARD (OR 1.35, 95% CI 0.63 to 3.08) had no effect on clinical outcomes of COVID-19.CONCLUSIONS:
AIRD does not increase susceptibility to COVID-19, not affecting the clinical outcome of COVID-19. Similarly, the use of steroids or csDMARDs for AIRD does not worsen the clinical outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Doenças Reumáticas
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Antirreumáticos
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Tratamento Farmacológico da COVID-19
Tipo de estudo:
Incidence_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article