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Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Merana, Geil R; Dwyer, Laura R; Dhariwala, Miqdad O; Weckel, Antonin; Gonzalez, Jeanmarie R; Okoro, Joy N; Cohen, Jarish N; Tamaki, Courtney M; Han, Jungmin; Tasoff, Preston; Palacios-Calderon, Yasmin; Ha, Connie W Y; Lynch, Susan V; Segre, Julia A; Kong, Heidi H; Kattah, Michael G; Ma, Averil; Scharschmidt, Tiffany C.
Afiliação
  • Merana GR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Dwyer LR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Dhariwala MO; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Weckel A; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Gonzalez JR; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Okoro JN; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Cohen JN; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Tamaki CM; Parnassus Flow Cytometry CoLab, University of California, San Francisco, San Francisco, 94143, USA.
  • Han J; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Tasoff P; Benioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA.
  • Palacios-Calderon Y; City College of San Francisco, San Francisco, CA 94112, USA.
  • Ha CWY; Benioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA.
  • Lynch SV; Benioff Center for Microbiome Medicine, Department of Medicine, University of California, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Segre JA; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kong HH; National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kattah MG; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Ma A; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Scharschmidt TC; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: tiffany.scharschmidt@ucsf.edu.
Cell Rep ; 39(9): 110891, 2022 05 31.
Article em En | MEDLINE | ID: mdl-35649365
Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic skin disorders suggest possible breakdown of this compartmentalization with disease. Using a model wherein neonatal skin colonization by Staphylococcus epidermidis facilitates generation of commensal-specific tolerance and CD4+ regulatory T cells (Tregs), we ask whether this response is perturbed by gut inflammation. Chemically induced colitis is accompanied by intestinal expansion of S. epidermidis and reduces gut-draining lymph node (dLN) commensal-specific Tregs. It also results in reduced commensal-specific Tregs in skin and skin-dLNs and increased skin neutrophils. Increased CD4+ circulation between gut and skin dLN suggests that the altered cutaneous response is initiated in the colon, and resistance to colitis-induced effects in Cd4creIl1r1fl/fl mice implicate interleukin (IL)-1 in mediating the altered commensal-specific response. These findings provide mechanistic insight into observed connections between inflammatory skin and intestinal diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Imunidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Imunidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos