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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Michel, Maurice; Benítez-Buelga, Carlos; Calvo, Patricia A; Hanna, Bishoy M F; Mortusewicz, Oliver; Masuyer, Geoffrey; Davies, Jonathan; Wallner, Olov; Sanjiv, Kumar; Albers, Julian J; Castañeda-Zegarra, Sergio; Jemth, Ann-Sofie; Visnes, Torkild; Sastre-Perona, Ana; Danda, Akhilesh N; Homan, Evert J; Marimuthu, Karthick; Zhenjun, Zhao; Chi, Celestine N; Sarno, Antonio; Wiita, Elisée; von Nicolai, Catharina; Komor, Anna J; Rajagopal, Varshni; Müller, Sarah; Hank, Emily C; Varga, Marek; Scaletti, Emma R; Pandey, Monica; Karsten, Stella; Haslene-Hox, Hanne; Loevenich, Simon; Marttila, Petra; Rasti, Azita; Mamonov, Kirill; Ortis, Florian; Schömberg, Fritz; Loseva, Olga; Stewart, Josephine; D'Arcy-Evans, Nicholas; Koolmeister, Tobias; Henriksson, Martin; Michel, Dana; de Ory, Ana; Acero, Lucia; Calvete, Oriol; Scobie, Martin; Hertweck, Christian; Vilotijevic, Ivan; Kalderén, Christina.
Afiliação
  • Michel M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Benítez-Buelga C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Calvo PA; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), 28029 Madrid, Spain.
  • Hanna BMF; Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), 28049 Madrid, Spain.
  • Mortusewicz O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Masuyer G; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Davies J; Department of Pharmacy and Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, UK.
  • Wallner O; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
  • Sanjiv K; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
  • Albers JJ; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Castañeda-Zegarra S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Jemth AS; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Visnes T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Sastre-Perona A; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491 Trondheim, Norway.
  • Danda AN; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Homan EJ; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
  • Marimuthu K; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
  • Zhenjun Z; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Chi CN; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Sarno A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Wiita E; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • von Nicolai C; Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
  • Komor AJ; Department of Environment and New Resources, SINTEF Ocean, N-7496 Trondheim, Norway.
  • Rajagopal V; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Müller S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Hank EC; Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Department of Biomolecular Chemistry, 07745 Jena, Germany.
  • Varga M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Scaletti ER; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Pandey M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Karsten S; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Haslene-Hox H; Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden.
  • Loevenich S; Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Marttila P; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Rasti A; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK.
  • Mamonov K; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Ortis F; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
  • Schömberg F; Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway.
  • Loseva O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Stewart J; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • D'Arcy-Evans N; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Koolmeister T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Henriksson M; Institute of Organic and Macromolecular Chemistry, Friedrich Schiller University Jena, 07743 Jena, Germany.
  • Michel D; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • de Ory A; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Acero L; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Calvete O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Scobie M; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden.
  • Hertweck C; Chemical Processes and Pharmaceutical Development, Unit Process Chemistry I, Research Institutes of Sweden - RISE, 151 36 Södertälje, Sweden.
  • Vilotijevic I; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
  • Kalderén C; Experimental Therapies and Novel Biomarkers in Cancer, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Science ; 376(6600): 1471-1476, 2022 06 24.
Article em En | MEDLINE | ID: mdl-35737787
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Estresse Oxidativo / DNA Glicosilases / Reparo do DNA Limite: Humans Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dano ao DNA / Estresse Oxidativo / DNA Glicosilases / Reparo do DNA Limite: Humans Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suécia