Serum L-Carnitine Levels Are Associated With First Stroke in Chinese Adults With Hypertension.
Stroke
; 53(10): 3091-3098, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35770671
ABSTRACT
BACKGROUND:
This study aimed to evaluate the association of serum L-carnitine with first stroke and explore potential effect modifiers.METHODS:
This is a nested, case-control study drawn from the China Stroke Primary Prevention Trial among rural Chinese adults with hypertension, including 557 first stroke cases and 557 age-matched, sex-matched, treatment group-matched, and residence-matched controls. Serum L-carnitine was measured by liquid chromatography with tandem quadrupole mass spectrometry. Multiple conditional logistic regression models were used to evaluate the association between L-carnitine and first stroke.RESULTS:
The mean level of serum L-carnitine in the stroke population was 4.7 µg/mL, which was significantly lower than that of the control group (5.7 µg/mL). When L-carnitine was assessed as quintiles, compared with the reference group (quintile 1, <3.3 µg/mL), the odds of stroke were 0.62 (95% CI, 0.39-1.00) in quintile 2, 0.66 (95% CI, 0.40-1.10) in quintile 3, 0.47 (95% CI, 0.28-0.81) in quintile 4, and 0.50 (95% CI, 0.30-0.84) in quintile 5. The trend test was significant (P=0.01). When quintiles 2 to 5 were combined, the adjusted odds ratio of first stroke was 0.58 (95% CI, 0.38-0.87) compared with quintile 1. Similar associations were found for ischemic stroke and hemorrhagic stroke. In subgroup analysis, a significant L-carnitine-stroke association was only observed in the normal folate group (P interaction, 0.039) and in the MTHFR CC genotype group (P interaction, 0.047).CONCLUSIONS:
In this study of rural Chinese adults with hypertension, serum L-carnitine had an inverse but nonlinear association with first stroke. Folate status and the MTHFR C677T variant were significant effect modifiers of the association.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
Hipertensão
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Stroke
Ano de publicação:
2022
Tipo de documento:
Article