Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage.
Pflugers Arch
; 474(10): 1069-1076, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35867189
ABSTRACT
Proinflammatory cytokines target vascular endothelial cells during COVID-19 infections. In particular, the endothelial glycocalyx (eGC), a proteoglycan-rich layer on top of endothelial cells, was identified as a vulnerable, vasoprotective structure during infections. Thus, eGC damage can be seen as a hallmark in the development of endothelial dysfunction and inflammatory processes. Using sera derived from patients suffering from COVID-19, we could demonstrate that the eGC became progressively worse in relation to disease severity (mild vs severe course) and in correlation to IL-6 levels. This could be prevented by administering low doses of spironolactone, a well-known and highly specific aldosterone receptor antagonist. Our results confirm that SARS-CoV-2 infections cause eGC damage and endothelial dysfunction and we outline the underlying mechanisms and suggest potential therapeutic options.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espironolactona
/
Glicocálix
/
Antagonistas de Receptores de Mineralocorticoides
/
SARS-CoV-2
/
COVID-19
/
Tratamento Farmacológico da COVID-19
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Alemanha