Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line.

Di, Da; Huang, Qinfeng; Ly, Hinh; Liang, Yuying

Di, Da; Huang, Qinfeng; Ly, Hinh; Liang, Yuying.

Afiliação

Di D; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.
Huang Q; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.
Ly H; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.
Liang Y; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.

J Virol ; 96(16): e0075422, 2022 08 24.

Article em En | MEDLINE | ID: mdl-35913216

Assuntos

Vírus Lassa; Proteínas Virais/metabolismo; Células HeLa; Humanos; Febre Lassa/virologia; Vírus Lassa/patogenicidade; Vírus Lassa/fisiologia; Vírus Pichinde/genética; Fatores de Virulência

Palavras-chave

Lassa; Lassa virus; Pichinde; Pichinde virus; RIG-I; RIG-I signaling; Z protein; arenavirus; inducible expression; innate immune evasion; innate immunity; recombinant viruses; tri-segmented arenavirus; viral virulence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Vírus Lassa Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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