CD 4+, CD 8+ and CD 19+cell surface antigen and abnormal mitochondria ultrastructure of peripheral blood P-type atypical lymphocytes in patients with schizophrenia.
World J Biol Psychiatry
; 24(4): 321-329, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-35950568
ABSTRACT
OBJECTIVE:
P-type atypical lymphocytes may play important roles in the aetiology and therapy of schizophrenia. However, there is merely a direct immunological characterisation of it. The aim of this study is to explore the surface antigens of these cells and their comparative ultrastructure in schizophrenia.METHODS:
We recruited 25 age-and gender-matched patients with unmedicated schizophrenia, other mental diseases and healthy individuals. Peripheral venous blood was smeared and stained. CD4+, CD8+ and CD19+ cell surface antigen- positive lymphocytes were purified using magnetic beads and prepared for light microscopy and electron microscopy.RESULTS:
The percentages of P-type atypical lymphocytes (34.53% ± 9.92%) were significantly higher (p < 0.0001) in schizophrenia than that of other mental diseases (9.79% ± 3.45%). These cells could present CD4+, CD8+ and CD19+ surface antigens. Their relative ultrastructure differed from that of normal lymphocytes, especially in mitochondria, which showed abundant, aggregated and quite irregular mitochondria; for example, slight dilation of the foci, swelling, degeneration, and even cavity.CONCLUSIONS:
P-type atypical lymphocytes could be found among CD4+, CD8+, and CD19 + lymphocytes with schizophrenia. Their abnormal ultrastructure of mitochondria implied that energy metabolism might play an important role in the aetiology of schizophrenia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
Limite:
Humans
Idioma:
En
Revista:
World J Biol Psychiatry
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2023
Tipo de documento:
Article