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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Tong, Huawei; Huang, Jia; Xiao, Qingquan; He, Bingbing; Dong, Xue; Liu, Yuanhua; Yang, Xiali; Han, Dingyi; Wang, Zikang; Wang, Xuchen; Ying, Wenqin; Zhang, Runze; Wei, Yu; Xu, Chunlong; Zhou, Yingsi; Li, Yanfei; Cai, Minqing; Wang, Qifang; Xue, Mingxing; Li, Guoling; Fang, Kailun; Zhang, Hainan; Yang, Hui.
Afiliação
  • Tong H; HuiGene Therapeutics Co., Ltd., Shanghai, China.
  • Huang J; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. jiahuang2022@163.com.
  • Xiao Q; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China. jiahuang2022@163.com.
  • He B; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Dong X; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Liu Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Yang X; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Han D; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Wang Z; Key Laboratory of Stem Cell Engineering and Regenerative Medicine of Fujian Provincial Colleges and Universities, Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
  • Wang X; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Ying W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Zhang R; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Wei Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Xu C; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Zhou Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Li Y; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Cai M; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Wang Q; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Xue M; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Li G; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Fang K; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, China.
  • Zhang H; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
  • Yang H; Zhoupu Hospital Affiliated to Shanghai Health Medical College and Shanghai Key Laboratory of MolecularImaging, Shanghai, China.
Nat Biotechnol ; 41(1): 108-119, 2023 01.
Article em En | MEDLINE | ID: mdl-35953673
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Sistemas CRISPR-Cas Limite: Animals Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA / Sistemas CRISPR-Cas Limite: Animals Idioma: En Revista: Nat Biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China