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Repurposing the Ionophore, PBT2, for Treatment of Multidrug-Resistant Neisseria gonorrhoeae Infections.
Jen, Freda E-C; Edwards, Jennifer L; El-Deeb, Ibrahim M; Walker, Mark J; von Itzstein, Mark; Jennings, Michael P.
Afiliação
  • Jen FE; Institute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast Campus, Queensland, Australia.
  • Edwards JL; The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Ohio, USA.
  • El-Deeb IM; Institute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast Campus, Queensland, Australia.
  • Walker MJ; School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queenslandgrid.1003.2, Queensland, Australia.
  • von Itzstein M; Institute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast Campus, Queensland, Australia.
  • Jennings MP; Institute for Glycomics, Griffith Universitygrid.1022.1, Gold Coast Campus, Queensland, Australia.
Antimicrob Agents Chemother ; 66(9): e0231821, 2022 09 20.
Article em En | MEDLINE | ID: mdl-35980187
ABSTRACT
Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 administered with zinc is shown to reverse resistance to antibiotics in several bacterial pathogens. Here we show that both N. meningitidis and MDR N. gonorrhoeae are sensitive to killing by PBT2 alone. PBT2 is, thus, a candidate therapeutic for MDR N. gonorrhoeae infections.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gonorreia / Neisseria meningitidis Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gonorreia / Neisseria meningitidis Limite: Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália