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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating.
Shivacharan, Rajat S; Rolle, Camarin E; Barbosa, Daniel A N; Cunningham, Tricia N; Feng, Austin; Johnson, Noriah D; Safer, Debra L; Bohon, Cara; Keller, Corey; Buch, Vivek P; Parker, Jonathon J; Azagury, Dan E; Tass, Peter A; Bhati, Mahendra T; Malenka, Robert C; Lock, James D; Halpern, Casey H.
Afiliação
  • Shivacharan RS; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Rolle CE; Department of Neurosurgery, Perelman School of Medicine, Richards Medical Research Laboratories, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA, USA.
  • Barbosa DAN; Department of Neurosurgery, Perelman School of Medicine, Richards Medical Research Laboratories, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA, USA.
  • Cunningham TN; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Feng A; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Johnson ND; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Safer DL; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Bohon C; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Keller C; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Buch VP; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Parker JJ; Veterans Affairs Palo Alto Healthcare System and the Sierra-Pacific Mental Illness Research Education, and Clinical Center, Palo Alto, CA, USA.
  • Azagury DE; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Tass PA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Bhati MT; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Malenka RC; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Lock JD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Halpern CH; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Nat Med ; 28(9): 1791-1796, 2022 09.
Article em En | MEDLINE | ID: mdl-36038628
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology during food cravings preceding LOC eating in two patients with BED and severe obesity (trial registration no. NCT03868670). Increased NAc low-frequency oscillations, prominent during food cravings, were used to guide DBS delivery. Over 6 months, we observed improved self-control of food intake and weight loss. These findings provide early support for restoring inhibitory control with electrophysiologically-guided NAc DBS. Further work with increased sample sizes is required to determine the scalability of this approach.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Estimulação Encefálica Profunda Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obesidade Mórbida / Estimulação Encefálica Profunda Limite: Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos