Comprehensive characterization of glucomannans from different sources to trigger moderate macrophages immune activation.
Carbohydr Polym
; 296: 119933, 2022 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-36087984
ABSTRACT
Macrophage activation is involved in the outcome of many diseases and is recognized as one of the best targets for disease intervention. Glucomannans had shown promising immunomodulatory potential. Herein, the activation performance of macrophages by glucomannans from different sources was thoroughly investigated. Glucomannans triggered the immune activation of macrophages, which was mainly manifested in increasing the secretion of immune effector molecules, enhancing the endocytosis and phagocytosis of macrophages, and selectively facilitating the expression of M1 phenotype. The participation of NF-κB and MAPK signaling pathways further validated the immune activation of macrophages by glucomannans. Correlation analysis indicated acetyl might be a feasible target for glucomannans to induce immune activation and the molecular weight (Mw) of glucomannans was also inseparable from the performance of immune activation. In conclusion, glucomannans showed a moderate immune activation effect on macrophages, and their difference in immune activation was closely related to the acetyl content and Mw.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação de Macrófagos
/
Mananas
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China