Molecular epidemiology of Orientia tsutsugamushi from outbreak regions, Madhya Pradesh, central India.
J Vector Borne Dis
; 59(2): 182-185, 2022.
Article
em En
| MEDLINE
| ID: mdl-36124485
ABSTRACT
Scrub typhus is a seriously neglected life threatening disease in Asia and the islands of the Pacific and Indian oceans. The causative agent is Orientia tsutsugamushi, an obligate intra-cytosolic bacterium transmitted to vertebrate animals such as human or rodent by larval trombiculid mites (chiggers). Here, we conducted an outbreak investigation in Madhya Pradesh state in central India after sudden upsurge in scrub typhus cases and mortality in humans. Sixty-five live traps were placed for capturing the rodents. The captured rodent species were identified and the samples were subjected to nested PCR targeting 56kDa TSA gene. Analysis revealed for the first-time predominant circulation of Karp genotype in this region. The vector species involved in transmission is Leptotrobidium deliense. In conclusion, we reported the circulation of Karp strain in outbreak regions of Madhya Pradesh and suggest that public health monitoring and surveillance needs to be improved. Studies on antigenic diversity, association of strains with clinical spectrum and pathogenicity in the local setup will be essential for development of region-specific diagnostics and vaccines.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientia tsutsugamushi
/
Tifo por Ácaros
Tipo de estudo:
Screening_studies
Limite:
Animals
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Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Vector Borne Dis
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Índia