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Rhodium(I)-catalyzed directed trideuteromethylation of (hetero)arene C-H bonds with CD3CO2D.
Zhao, Haoqiang; Zeng, Qi; Yang, Ji; Xu, Bing; Lei, Haimin; Xu, Lijin; Walsh, Patrick J.
Afiliação
  • Zhao H; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. hq-zhao@bucm.edu.cn.
  • Zeng Q; Department of Chemistry, Renmin University of China, Beijing 100872, China. 20050062@ruc.edu.cn.
  • Yang J; Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA. pwalsh@sas.upenn.edu.
  • Xu B; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. hq-zhao@bucm.edu.cn.
  • Lei H; Department of Chemistry, Renmin University of China, Beijing 100872, China. 20050062@ruc.edu.cn.
  • Xu L; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. hq-zhao@bucm.edu.cn.
  • Walsh PJ; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. hq-zhao@bucm.edu.cn.
Org Biomol Chem ; 20(38): 7645-7649, 2022 10 05.
Article em En | MEDLINE | ID: mdl-36125438
ABSTRACT
A Rh(I)-catalyzed trideuteromethylation of heteroarenes with inexpensive and readily available deuterated acetic acid (CD3CO2D) with the aid of a N-containing directing groups is developed. The oxidant-free reaction is applicable to a wide range of heteroarene substrates, including 2-pyridones, indoles, aryl rings, pyrroles and carbazoles. It allows installation of CD3 groups under straightforward reaction conditions. It is expected that the salient and practical features of this trideuteromethylation protocol will be of use to academic and industrial researchers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ródio Tipo de estudo: Guideline Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ródio Tipo de estudo: Guideline Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China