Effect of carrier molecular weight on physicochemical properties and the in vitro immune-stimulatory activity of the CpG-dextran conjugates.

Nguyen, Hien V; Campbell, Katrin; Painter, Gavin F; Young, Sarah L; Walker, Greg F

Nguyen, Hien V; Campbell, Katrin; Painter, Gavin F; Young, Sarah L; Walker, Greg F.

Afiliação

Nguyen HV; School of Pharmacy, University of Otago, Dunedin 9016, New Zealand; Faculty of Pharmacy, Van Lang University, Ho Chi Minh City 700000, Vietnam.
Campbell K; Department of Pathology, University of Otago, Dunedin 9016, New Zealand.
Painter GF; The Ferrier Research Institute, Victoria University of Wellington, Wellington 5040, New Zealand.
Young SL; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia.
Walker GF; School of Pharmacy, University of Otago, Dunedin 9016, New Zealand. Electronic address: greg.walker@otago.ac.nz.

Int J Pharm ; 627: 122236, 2022 Nov 05.

Article em En | MEDLINE | ID: mdl-36174851

Assuntos

Células Dendríticas; Fator de Necrose Tumoral alfa; Fator de Necrose Tumoral alfa/metabolismo; Interleucina-6/metabolismo; Peso Molecular; Fosfatos/metabolismo; Dextranos/metabolismo; Citosina; Guanina; Citocinas; Oligodesoxirribonucleotídeos/farmacologia; Desoxirribonuclease I; Hidrazonas/farmacologia

Palavras-chave

Amino-dextran; Bis-aryl hydrazone; CpG oligodeoxynucleotide; Immunostimulatory activity; Nuclease stability; Polymeric conjugate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Fator de Necrose Tumoral alfa Tipo de estudo: Prognostic_studies Idioma: En Revista: Int J Pharm Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Vietnã

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