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A patient-driven clinicogenomic partnership for metastatic prostate cancer.
Crowdis, Jett; Balch, Sara; Sterlin, Lauren; Thomas, Beena S; Camp, Sabrina Y; Dunphy, Michael; Anastasio, Elana; Shah, Shahrayz; Damon, Alyssa L; Ramos, Rafael; Sosa, Delia M; Small, Ilan K; Tomson, Brett N; Nguyen, Colleen M; McGillicuddy, Mary; Chastain, Parker S; He, Meng Xiao; Cheung, Alexander T M; Wankowicz, Stephanie; Tewari, Alok K; Kim, Dewey; AlDubayan, Saud H; Dowdye, Ayanah; Zola, Benjamin; Nowak, Joel; Manarite, Jan; Gunn, Idola Henry; Olson, Bryce; Lander, Eric S; Painter, Corrie A; Wagle, Nikhil; Van Allen, Eliezer M.
Afiliação
  • Crowdis J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Balch S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Sterlin L; These authors contributed equally.
  • Thomas BS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Camp SY; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Dunphy M; These authors contributed equally.
  • Anastasio E; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Shah S; Count Me In, Cambridge, MA 02142, USA.
  • Damon AL; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Ramos R; Count Me In, Cambridge, MA 02142, USA.
  • Sosa DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Small IK; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Tomson BN; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Nguyen CM; Count Me In, Cambridge, MA 02142, USA.
  • McGillicuddy M; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Chastain PS; Count Me In, Cambridge, MA 02142, USA.
  • He MX; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Cheung ATM; Count Me In, Cambridge, MA 02142, USA.
  • Wankowicz S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Tewari AK; Count Me In, Cambridge, MA 02142, USA.
  • Kim D; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • AlDubayan SH; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Dowdye A; Count Me In, Cambridge, MA 02142, USA.
  • Zola B; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Nowak J; Count Me In, Cambridge, MA 02142, USA.
  • Manarite J; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Gunn IH; Count Me In, Cambridge, MA 02142, USA.
  • Olson B; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Lander ES; Count Me In, Cambridge, MA 02142, USA.
  • Painter CA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Wagle N; Count Me In, Cambridge, MA 02142, USA.
  • Van Allen EM; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Cell Genom ; 2(9)2022 Sep 14.
Article em En | MEDLINE | ID: mdl-36177448
ABSTRACT
Molecular profiling studies have enabled discoveries for metastatic prostate cancer (MPC) but have predominantly occurred in academic medical institutions and involved non-representative patient populations. We established the Metastatic Prostate Cancer Project (MPCproject, mpcproject.org), a patient-partnered initiative to involve patients with MPC living anywhere in the US and Canada in molecular research. Here, we present results from our partnership with the first 706 MPCproject participants. While 41% of patient partners live in rural, physician-shortage, or medically underserved areas, the MPCproject has not yet achieved racial diversity, a disparity that demands new initiatives detailed herein. Among molecular data from 333 patient partners (572 samples), exome sequencing of 63 tumor and 19 cell-free DNA (cfDNA) samples recapitulated known findings in MPC, while inexpensive ultra-low-coverage sequencing of 318 cfDNA samples revealed clinically relevant AR amplifications. This study illustrates the power of a growing, longitudinal partnership with patients to generate a more representative understanding of MPC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Genom Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos