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Electronic cigarette vaping with aged coils causes acute lung injury in mice.
Goto, Shunsaku; Grange, Robert M H; Pinciroli, Riccardo; Rosales, Ivy A; Li, Rebecca; Boerboom, Sophie L; Ostrom, Katrina F; Marutani, Eizo; Wanderley, Hatus V; Bagchi, Aranya; Colvin, Robert B; Berra, Lorenzo; Minaeva, Olga; Goldstein, Lee E; Malhotra, Rajeev; Zapol, Warren M; Ichinose, Fumito; Yu, Binglan.
Afiliação
  • Goto S; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Grange RMH; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Pinciroli R; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Rosales IA; Immunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Li R; Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Boerboom SL; Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Ostrom KF; Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Marutani E; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Wanderley HV; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Bagchi A; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Colvin RB; Immunopathology Research Laboratory, Department of Pathology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Berra L; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
  • Minaeva O; Center for Biometals & Metallomics, Department of Radiology, Boston University School of Medicine, Boston University Alzheimer' Disease Center, Boston, MA, 02118, USA.
  • Goldstein LE; College of Engineering, Photonics Center, Boston University, Boston, MA, 02215, USA.
  • Malhotra R; Center for Biometals & Metallomics, Department of Radiology, Boston University School of Medicine, Boston University Alzheimer' Disease Center, Boston, MA, 02118, USA.
  • Zapol WM; College of Engineering, Photonics Center, Boston University, Boston, MA, 02215, USA.
  • Ichinose F; Cardiovascular Research Center and Corrigan Minehan Heart Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Yu B; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Thier Research Building 505, Boston, MA, 02114, USA.
Arch Toxicol ; 96(12): 3363-3371, 2022 12.
Article em En | MEDLINE | ID: mdl-36195745
ABSTRACT
Electronic cigarettes (e-cigarettes) have been used widely as an alternative to conventional cigarettes and have become particularly popular among young adults. A growing body of evidence has shown that e-cigarettes are associated with acute lung injury and adverse effects in multiple other organs. Previous studies showed that high emissions of aldehydes (formaldehyde and acetaldehyde) in aerosols were associated with increased usage of the same e-cigarette coils. However, the impact on lung function of using aged coils has not been reported. We investigated the relationship between coil age and acute lung injury in mice exposed to experimental vaping for 1 h (2 puffs/min, 100 ml/puff). The e-liquid contains propylene glycol and vegetable glycerin (5050, vol) only. The concentrations of formaldehyde and acetaldehyde in the vaping aerosols increased with age of the nichrome coils starting at 1200 puffs. Mice exposed to e-cigarette aerosols produced from 1800, but not 0 or 900, puff-aged coils caused acute lung injury, increased lung wet/dry weight ratio, and induced lung inflammation (IL-6, TNF-α, IL-1ß, MIP-2). Exposure to vaping aerosols from 1800 puff-aged coils decreased heart rate, respiratory rate, and oxygen saturation in mice compared to mice exposed to air or aerosols from new coils. In conclusion, we observed that the concentration of aldehydes (formaldehyde and acetaldehyde) increased with repeated and prolonged usage of e-cigarette coils. Exposure to high levels of aldehyde in vaping aerosol was associated with acute lung injury in mice. These findings show significant risk of lung injury associated with prolonged use of e-cigarette devices.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Sistemas Eletrônicos de Liberação de Nicotina / Vaping Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Arch Toxicol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Sistemas Eletrônicos de Liberação de Nicotina / Vaping Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Arch Toxicol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos