BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation.

Jiang, Zhi; Wang, Jie; Sun, Gaohui; Feng, Meijiang

Jiang, Zhi; Wang, Jie; Sun, Gaohui; Feng, Meijiang.

Afiliação

Jiang Z; Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing 210011, China; Department of Neurology, The Second People's Hospital of NanTong, Nantong 226006, China.
Wang J; Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing 210011, China; Department of Neurology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China.
Sun G; Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing 210011, China.
Feng M; Department of Geriatrics, The Second Affiliated Hospital, Key Laboratory for Aging & Disease, Nanjing Medical University, Nanjing 210011, China. Electronic address: mjfeng416@163.com.

Mol Cell Neurosci ; 123: 103784, 2022 12.

Article em En | MEDLINE | ID: mdl-36228967

Assuntos

Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais; Doenças Neurodegenerativas; Doença de Parkinson; Humanos; Ratos; Animais; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Doença de Parkinson/terapia; Doença de Parkinson/metabolismo; Dopamina/metabolismo; Transplante de Células-Tronco Mesenquimais/métodos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptor 4 Toll-Like/metabolismo; Neuroproteção; Doenças Neurodegenerativas/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; Fator 88 de Diferenciação Mieloide/farmacologia; Fosfatidilinositol 3-Quinases/metabolismo; Ratos Sprague-Dawley; Neurônios/metabolismo; Cordão Umbilical/metabolismo; Neurônios Dopaminérgicos/metabolismo

Palavras-chave

Anti-neuroinflammation; Brain-derived neurotrophic factor; Dopaminergic-like neurons; Human umbilical cord mesenchymal stem cells; Neuroprotection; Parkinson's disease

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Doenças Neurodegenerativas / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais Limite: Animals / Humans Idioma: En Revista: Mol Cell Neurosci Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google