Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-<i>&#954;</i>B Signaling Pathways in Human Gingival Fibroblasts.

Kim, Jeong-Mi; Noh, Eun-Mi; You, Yong-Ouk; Kim, Min Seuk; Lee, Young-Rae

Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-κB Signaling Pathways in Human Gingival Fibroblasts.

Kim, Jeong-Mi; Noh, Eun-Mi; You, Yong-Ouk; Kim, Min Seuk; Lee, Young-Rae.

Afiliação

Kim JM; Department of Biochemistry, Jeonbuk National University Medical School, Jeonju-si, Jeollabuk-do 54896, Republic of Korea.
Noh EM; Department of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.
You YO; Department of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.
Kim MS; Department of Oral Physiology, And Institute of Biomaterial-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.
Lee YR; Department of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.

Biomed Res Int ; 2022: 3865844, 2022.

Article em En | MEDLINE | ID: mdl-36246974

Assuntos

Fibroblastos; Metaloproteinase 1 da Matriz; Periodontite; Serina Endopeptidases; Citocinas/metabolismo; Regulação para Baixo; Fibroblastos/metabolismo; Humanos; Interleucina-1/metabolismo; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Lipopolissacarídeos/toxicidade; Metaloproteinase 1 da Matriz/genética; Metaloproteinase 1 da Matriz/metabolismo; NF-kappa B/metabolismo; Periodontite/genética; Periodontite/metabolismo; Porphyromonas gingivalis; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/metabolismo; Receptores Ativados por Proteinase/metabolismo; Serina Endopeptidases/genética; Serina Endopeptidases/metabolismo; Transdução de Sinais; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Serina Endopeptidases / Metaloproteinase 1 da Matriz / Fibroblastos Limite: Humans Idioma: En Revista: Biomed Res Int Ano de publicação: 2022 Tipo de documento: Article

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