Mapping Proteome and Lipidome Changes in Early-Onset Non-Alcoholic Fatty Liver Disease Using Hepatic 3D Spheroids.

Frandsen, Helle Sedighi; Vej-Nielsen, Joel Mario; Smith, Lauren Elizabeth; Sun, Lang; Mikkelsen, Karoline Lindgaard; Thulesen, Annemette Præstegaard; Hagensen, Christina Erika; Yang, Fuquan; Rogowska-Wrzesinska, Adelina

Frandsen, Helle Sedighi; Vej-Nielsen, Joel Mario; Smith, Lauren Elizabeth; Sun, Lang; Mikkelsen, Karoline Lindgaard; Thulesen, Annemette Præstegaard; Hagensen, Christina Erika; Yang, Fuquan; Rogowska-Wrzesinska, Adelina.

Afiliação

Frandsen HS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Vej-Nielsen JM; Sino-Danish College (SDC), University of Chinese Academy of Sciences, 380 Huaibeizhuang, Beijing 100101, China.
Smith LE; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Sun L; Sino-Danish College (SDC), University of Chinese Academy of Sciences, 380 Huaibeizhuang, Beijing 100101, China.
Mikkelsen KL; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Thulesen AP; Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hagensen CE; University of Chinese Academy of Sciences, Beijing 101408, China.
Yang F; Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Rogowska-Wrzesinska A; CelVivo ApS, 5491 Blommenslyst, Denmark.

Cells ; 11(20)2022 10 13.

Article em En | MEDLINE | ID: mdl-36291085

Assuntos

Lipidômica; Hepatopatia Gordurosa não Alcoólica; Humanos; Trifosfato de Adenosina/metabolismo; Caderinas/metabolismo; Ceramidas/metabolismo; Transição Epitelial-Mesenquimal; Hepatopatia Gordurosa não Alcoólica/metabolismo; Ácido Oleico/metabolismo; Ácido Palmítico/metabolismo; Proteoma/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Triglicerídeos/metabolismo; Células Hep G2

Palavras-chave

3-dimensional cell culture; NAFLD; fatty liver disease; human hepatocytes; lipidomics; proteomics; spheroids; steatosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica / Lipidômica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cells Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Dinamarca

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