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Coronary artery calcification in patients with advanced chronic kidney disease.
Xiang, Xiadan; He, Ji; Zhang, Wei; He, Qiang; Liu, Yueming.
Afiliação
  • Xiang X; Department of Nephrology, the Second affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • He J; Urology & Nephrology Center, Department of Nephrology, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Zhang W; Urology & Nephrology Center, Department of Nephrology, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • He Q; Urology & Nephrology Center, Department of Nephrology, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
  • Liu Y; Urology & Nephrology Center, Department of Nephrology, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Lyman6136@126.com.
BMC Cardiovasc Disord ; 22(1): 453, 2022 10 29.
Article em En | MEDLINE | ID: mdl-36309659
INTRODUCTION: Cardiovascular disease (CVD) is associated with higher morbidity and mortality rates in patients with chronic kidney disease (CKD). Studies have shown that vascular calcification is a major predictor of CVD. Vascular calcification in the CKD population is associated with various risk factors, and changes in bone and mineral metabolism have been linked to an increased risk of atherosclerosis. Therefore, we aimed to investigate the correlation between vascular calcification and bone metabolism, which is necessary to improve the survival and prognosis of patients with CKD. METHODS: We included 146 patients with CKD who received coronary artery calcification (CAC) scores at our hospital from May 2017 to November 2018. Spearman rank correlation analysis, Mann-Whitney U test, and Kaplan-Meier method were used to analyze laboratory data and all-cause mortality. RESULTS: In the 146 patients, chronic glomerulonephritis accounted for the most common cause of CKD, at approximately 39.0%. Spearman rank correlation analysis on the factors influencing vascular calcification in patients with CKD showed that CAC score was significantly and positively correlated with C-reactive protein, N-terminal/midregion osteocalcin (N-MID), N-terminal peptide of type 1 procollagen (P1NP), ß-cross-linked C-telopeptide of type 1 collagen (ß-CTx), and parathyroid hormone (P = 0.0423, P = 0.0432, P = 0.0235, P = 0.0061, P < 0.0001, respectively). Serum calcium levels were positively correlated with N-MID, P1NP, ß-CTx, and iPTH (r = 0.19, r = 0.24, r = 0.21, r = 0.21, respectively), and serum phosphorus levels were positively correlated with N-MID, P1NP, ß-CTx, and iPTH (r = 0.50, r = 0.37, r = 0.50, r = 0.55, respectively). However, no difference was found in CVC scores among patients with CKD in different stages and receiving different treatments. In the Kaplan-Meier analysis of all-cause hospitalization and mortality rates, patients with CAC > 400 had a higher risk. CONCLUSION: We found that the primary cause of CKD is glomerulonephritis, and the CAC score is positively correlated with inflammatory and bone metabolism markers, with a higher risk of all-cause mortality and cardiovascular hospitalization when the CAC score is greater than 400.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Doenças Cardiovasculares / Insuficiência Renal Crônica / Calcificação Vascular / Glomerulonefrite Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Cardiovasc Disord Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Doenças Cardiovasculares / Insuficiência Renal Crônica / Calcificação Vascular / Glomerulonefrite Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: BMC Cardiovasc Disord Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China