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Cardiac MRI Risk Stratification for Dilated Cardiomyopathy with Left Ventricular Ejection Fraction of 35% or Higher.
Li, Shuang; Wang, Yining; Yang, Wenjing; Zhou, Di; Zhuang, Baiyan; Xu, Jing; He, Jian; Yin, Gang; Fan, Xiaohan; Wu, Weichun; Sharma, Piyush; Sirajuddin, Arlene; Arai, Andrew E; Zhao, Shihua; Lu, Minjie.
Afiliação
  • Li S; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Wang Y; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Yang W; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Zhou D; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Zhuang B; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Xu J; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • He J; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Yin G; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Fan X; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Wu W; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Sharma P; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Sirajuddin A; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Arai AE; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Zhao S; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
  • Lu M; From the Department of Magnetic Resonance Imaging (S.L., Y.W., W.Y., D.Z., B.Z., J.X., J.H., G.Y., S.Z., M.L.), Cardiac Arrhythmia Center (X.F.), and Department of Echocardiography (W.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Ch
Radiology ; 306(3): e213059, 2023 03.
Article em En | MEDLINE | ID: mdl-36318031
ABSTRACT
Background Studies over the past 15 years have demonstrated that a considerable number of patients with dilated cardiomyopathy (DCM) who died from sudden cardiac death (SCD) had a left ventricular (LV) ejection fraction (LVEF) of 35% or higher. Purpose To identify clinical and cardiac MRI risk factors for adverse events in patients with DCM and LVEF of 35% or higher. Materials and Methods In this retrospective study, consecutive patients with DCM and LVEF of 35% or higher who underwent cardiac MRI between January 2010 and December 2017 were included. The primary end point was a composite of SCD or aborted SCD. The secondary end point was a composite of all-cause mortality, heart transplant, or hospitalization for heart failure. The risk factors for the primary and secondary end points were identified with multivariable Cox analysis. Results A total of 466 patients with DCM and LVEF of 35% or higher (mean age, 44 years ± 14 [SD]; 358 men) were included. During a mean follow-up of 79 months ± 30 (SD) (range, 7-143 months), 40 patients reached the primary end point and 61 reached the secondary end point. In the adjusted analysis, age (hazard ratio [HR], 1.03 per year [95% CI 1.00, 1.05]; P = .04), family history of SCD (HR, 3.4 [95% CI 1.3, 8.8]; P = .01), New York Heart Association (NYHA) class III or IV (HR vs NYHA class I or II, 2.1 [95% CI 1.1, 3.9]; P = .02), and myocardial scar at late gadolinium enhancement (LGE) MRI greater than or equal to 7.1% of the LV mass (HR, 4.4 [95% CI 2.4, 8.3]; P < .001) were associated with SCD or aborted SCD. For the composite secondary end point, LGE greater than or equal to 7.1% of the LV mass (HR vs LGE <7.1%, 2.0 [95% CI 1.2, 3.4]; P = .01), left atrial maximum volume index, and reduced global longitudinal strain were independent predictors. Conclusion For patients with dilated cardiomyopathy and left ventricular (LV) ejection fraction of 35% or higher, cardiac MRI-defined myocardial scar greater than or equal to 7.1% of the LV mass was associated with sudden cardiac death (SCD) or aborted SCD. © RSNA, 2022 Online supplemental material is available for this article.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Função Ventricular Esquerda Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Radiology Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Função Ventricular Esquerda Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Radiology Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça