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MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Cheng, Dong; Zinker, Bradley A; Luo, Yi; Shipkova, Petia; De Oliveira, Claudia H; Krishna, Gopal; Brown, Elizabeth A; Boehm, Stephanie L; Tirucherai, Giridhar S; Gu, Huidong; Ma, Zhengping; Chu, Ching-Hsuen; Onorato, Joelle M; Kopcho, Lisa M; Ammar, Ron; Smith, Julia; Devasthale, Pratik; Lawrence, R Michael; Stryker, Steven A; Dierks, Elizabeth A; Azzara, Anthony V; Carayannopoulos, Leon; Charles, Edgar D; Lentz, Kimberley A; Gordon, David A.
Afiliação
  • Cheng D; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA. Electronic address: dong.cheng@bms.com.
  • Zinker BA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Luo Y; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.
  • Shipkova P; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • De Oliveira CH; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.
  • Krishna G; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA.
  • Brown EA; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Boehm SL; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Tirucherai GS; Clinical Pharmacology, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.
  • Gu H; Translational Medicine, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.
  • Ma Z; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Chu CH; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Onorato JM; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Kopcho LM; Leads Discovery and Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Ammar R; Translational Bioinformatics, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Smith J; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Devasthale P; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Lawrence RM; Small Molecule Drug Discovery, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Stryker SA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Dierks EA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Azzara AV; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Carayannopoulos L; ICF Early Clinical Development, Bristol Myers Squibb, Summit, NJ 07901, USA.
  • Charles ED; Global Drug Development, Bristol Myers Squibb, Lawrenceville, NJ 08543, USA.
  • Lentz KA; Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Princeton, NJ 08543, USA.
  • Gordon DA; Departments of Discovery Biology Cardiovascular and Fibrosis, Bristol Myers Squibb, Princeton, NJ 08543, USA.
Cell Metab ; 34(11): 1732-1748.e5, 2022 11 01.
Article em En | MEDLINE | ID: mdl-36323235
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica / Obesidade Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatopatia Gordurosa não Alcoólica / Obesidade Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2022 Tipo de documento: Article