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Microglia states and nomenclature: A field at its crossroads.
Paolicelli, Rosa C; Sierra, Amanda; Stevens, Beth; Tremblay, Marie-Eve; Aguzzi, Adriano; Ajami, Bahareh; Amit, Ido; Audinat, Etienne; Bechmann, Ingo; Bennett, Mariko; Bennett, Frederick; Bessis, Alain; Biber, Knut; Bilbo, Staci; Blurton-Jones, Mathew; Boddeke, Erik; Brites, Dora; Brône, Bert; Brown, Guy C; Butovsky, Oleg; Carson, Monica J; Castellano, Bernardo; Colonna, Marco; Cowley, Sally A; Cunningham, Colm; Davalos, Dimitrios; De Jager, Philip L; de Strooper, Bart; Denes, Adam; Eggen, Bart J L; Eyo, Ukpong; Galea, Elena; Garel, Sonia; Ginhoux, Florent; Glass, Christopher K; Gokce, Ozgun; Gomez-Nicola, Diego; González, Berta; Gordon, Siamon; Graeber, Manuel B; Greenhalgh, Andrew D; Gressens, Pierre; Greter, Melanie; Gutmann, David H; Haass, Christian; Heneka, Michael T; Heppner, Frank L; Hong, Soyon; Hume, David A; Jung, Steffen.
Afiliação
  • Paolicelli RC; Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. Electronic address: rosachiara.paolicelli@unil.ch.
  • Sierra A; Achucarro Basque Center for Neuroscience, Glial Cell Biology Lab, Leioa, Spain; Department of Neuroscience, University of the Basque Country EHU/UPV, Leioa, Spain; Ikerbasque Foundation, Bilbao, Spain. Electronic address: amanda.sierra@ehu.eus.
  • Stevens B; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, (HHMI), MD, USA; Boston Children's Hospital, Boston, MA, USA. Electronic address: beth.stevens@childrens.harvard.edu.
  • Tremblay ME; Centre de recherche du CHU de Québec-Université Laval, Québec City, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Center for Advanced Materials and Related Technology (CAMTEC)
  • Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.
  • Ajami B; Department of Molecular Microbiology & Immunology, Department of Behavioral and Systems Neuroscience, Oregon Health & Science University School of Medicine, Portland, OR, USA.
  • Amit I; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
  • Audinat E; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France.
  • Bechmann I; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • Bennett M; Children's Hospital of Philadelphia, Department of Psychiatry, Department of Pediatrics, Division of Child Neurology, Philadelphia, PA, USA.
  • Bennett F; Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
  • Bessis A; École Normale Supérieure, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Paris Sciences et Lettres Research University, Paris, France.
  • Biber K; Neuroscience Discovery, AbbVie Deutschland GmbH, Ludwigshafen, Germany.
  • Bilbo S; Departments of Psychology & Neuroscience, Neurobiology, and Cell Biology, Duke University, Durham, NC, USA.
  • Blurton-Jones M; Center for the Neurobiology of Learning and Memory, UCI MIND, University of California, Irvine, CA, USA.
  • Boddeke E; Department Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center, Groningen, the Netherlands.
  • Brites D; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
  • Brône B; BIOMED Research Institute, University of Hasselt, Hasselt, Belgium.
  • Brown GC; Department of Biochemistry, University of Cambridge, Cambridge, UK.
  • Butovsky O; Ann Romney Center for Neurologic Diseases, Department Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Carson MJ; Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, University of California Riverside School of Medicine, Riverside, CA, USA.
  • Castellano B; Unidad de Histología Medica, Depto. Biología Celular, Fisiología e Inmunología, Barcelona, Spain; Instituto de Neurociencias, Universidad Autónoma de Barcelona, Barcelona, Spain.
  • Colonna M; Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Cowley SA; James and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
  • Cunningham C; School of Biochemistry & Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Republic of Ireland; Trinity College Institute of Neuroscience, Trinity College, Dublin, Republic of Ireland.
  • Davalos D; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
  • De Jager PL; Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
  • de Strooper B; UK Dementia Research Institute at University College London, London, UK; Vlaams Instituut voor Biotechnologie at Katholieke Universiteit Leuven, Leuven, Belgium.
  • Denes A; "Momentum" Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Eggen BJL; Department of Biomedical Sciences of Cells & Systems, section Molecular Neurobiology, University of Groningen, Groningen, the Netherlands; University Medical Center Groningen, Groningen, the Netherlands.
  • Eyo U; Department of Neuroscience, Center for Brain Immunology and Glia, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Galea E; Institut de Neurociències and Departament de Bioquímica, Unitat de Bioquímica, Universitat Autònoma de Barcelona, Barcelona, Spain; ICREA, Barcelona, Spain.
  • Garel S; Institut de Biologie de l'ENS (IBENS), Département de Biologie, École Normale Supérieure, CNRS, INSERM, Paris, France; College de France, Paris, France.
  • Ginhoux F; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A(∗)STAR), Singapore, Singapore.
  • Glass CK; University of California San Diego School of Medicine, La Jolla, CA, USA.
  • Gokce O; Institute for Stroke and Dementia Research, Ludwig Maximillian's University of Munich, Munich, Germany.
  • Gomez-Nicola D; School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK.
  • González B; Unidad de Histología Medica, Depto. Biología Celular, Fisiología e Inmunología and Instituto de Neurociencias, Universidad Autónoma de Barcelona, Barcelona, Spain.
  • Gordon S; Chang Gung University, Taoyuan City, Taiwan (ROC); Sir William Dunn School of Pathology, Oxford, UK.
  • Graeber MB; Ken Parker Brain Tumour Research Laboratories, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.
  • Greenhalgh AD; Lydia Becker Institute of Immunology and Inflammation, Geoffrey Jefferson Brain Research Centre, Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
  • Gressens P; Université Paris Cité, Inserm, NeuroDiderot, 75019 Paris, France.
  • Greter M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Gutmann DH; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Haass C; Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), Ludwig-Maximilians-Universität Munchen, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy); Munich, Germany.
  • Heneka MT; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
  • Heppner FL; Department of Neuropathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Hong S; UK Dementia Research Institute at University College London, London, UK.
  • Hume DA; Mater Research Institute-University of Queensland, Brisbane, QLD, Australia.
  • Jung S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.
Neuron ; 110(21): 3458-3483, 2022 11 02.
Article em En | MEDLINE | ID: mdl-36327895
ABSTRACT
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article