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AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys25-Cys192) formation of functional significance for VIPR2.
Sakamoto, Kotaro; Asano, Satoshi; Ago, Yukio; Hirokawa, Takatsugu.
Afiliação
  • Sakamoto K; Research and Development Department, Ichimaru Pharcos Company Limited, 318-1 Asagi, Motosu, 501-0475, Gifu, Japan. Electronic address: sakamoto-kotaro@ichimaru.co.jp.
  • Asano S; Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan.
  • Ago Y; Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8553, Hiroshima, Japan.
  • Hirokawa T; Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Japan; Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, 305-8575, Tsukuba, Japan. Electronic address: t-hirokawa@md.tsukuba.ac.jp.
Biochem Biophys Res Commun ; 636(Pt 1): 10-16, 2022 12 25.
Article em En | MEDLINE | ID: mdl-36332470
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Peptídeo Intestinal Vasoativo / Receptores Tipo II de Peptídeo Intestinal Vasoativo Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Peptídeo Intestinal Vasoativo / Receptores Tipo II de Peptídeo Intestinal Vasoativo Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article