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Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.
Sakai, Katsuya; Sugano-Nakamura, Nozomi; Mihara, Emiko; Rojas-Chaverra, Nichole Marcela; Watanabe, Sayako; Sato, Hiroki; Imamura, Ryu; Voon, Dominic Chih-Cheng; Sakai, Itsuki; Yamasaki, Chihiro; Tateno, Chise; Shibata, Mikihiro; Suga, Hiroaki; Takagi, Junichi; Matsumoto, Kunio.
Afiliação
  • Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. k_sakai@staff.kanazawa-u.ac.jp.
  • Sugano-Nakamura N; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan. k_sakai@staff.kanazawa-u.ac.jp.
  • Mihara E; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Japan.
  • Rojas-Chaverra NM; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Japan.
  • Watanabe S; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
  • Sato H; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita, Japan.
  • Imamura R; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
  • Voon DC; Tumor Microenvironment Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan.
  • Sakai I; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
  • Yamasaki C; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan.
  • Tateno C; Inflammation and Epithelial Plasticity Unit, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
  • Shibata M; Cancer Model Research Innovative Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan.
  • Suga H; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
  • Takagi J; Research and Development Department, PhoenixBio Co. Ltd, Higashihiroshima, Japan.
  • Matsumoto K; Research and Development Department, PhoenixBio Co. Ltd, Higashihiroshima, Japan.
Nat Biomed Eng ; 7(2): 164-176, 2023 02.
Article em En | MEDLINE | ID: mdl-36344661
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Barreira Hematoencefálica Limite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Barreira Hematoencefálica Limite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão