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Discovery of two biotin-PEG4­diarylidenyl piperidone prodrugs as potent antitumor agents with good efficacy, limited toxicity, and low resistance.
Liu, Shuang-Qiang; Mao, Zhi-Chen; Xu, Yan-Li; Chen, Xiao-Man; Wang, Hui-Ling; Wang, Qi; Wei, Jian-Hua; Huang, Ri-Zhen; Zhang, Ye.
Afiliação
  • Liu SQ; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China; Guangxi Key Laboratory of Molecular Medicine in Liver Injury and
  • Mao ZC; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China.
  • Xu YL; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China.
  • Chen XM; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China.
  • Wang HL; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China.
  • Wang Q; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China.
  • Wei JH; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China; Guangxi Key Laboratory of Molecular Medicine in Liver Injury and
  • Huang RZ; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China. Electronic address: rzhuang1783@163.com.
  • Zhang Y; Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin 541199, PR China; Guangxi Key Laboratory of Molecular Medicine in Liver Injury and
Bioorg Chem ; 131: 106323, 2023 02.
Article em En | MEDLINE | ID: mdl-36538834
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article