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Relationships of body composition and adipocytokines with outcomes in metastatic castration-resistant prostate cancer patients receiving docetaxel chemotherapy.
Li, Jun-Hong; Zhang, Xing-Ming; Bian, Xiao-Jie; Gu, Wei-Jie; Wan, Fang-Ning; Dai, Bo; Ye, Ding-Wei.
Afiliação
  • Li JH; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Zhang XM; Shanghai Genitourinary Cancer Institute, Shanghai 200032, China.
  • Bian XJ; Shanghai Genitourinary Cancer Institute, Shanghai 200032, China.
  • Gu WJ; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Wan FN; Shanghai Genitourinary Cancer Institute, Shanghai 200032, China.
  • Dai B; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • Ye DW; Shanghai Genitourinary Cancer Institute, Shanghai 200032, China.
Asian J Androl ; 25(4): 520-527, 2023.
Article em En | MEDLINE | ID: mdl-36629156
ABSTRACT
We evaluated the relationships of body composition and serum adipocytokine levels with progression-free survival (PFS) and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving docetaxel. The medical records of mCRPC patients who received docetaxel between January 2011 and December 2015 at Fudan University Shanghai Cancer Center (Shanghai, China) were reviewed. The following body composition parameters were calculated using computed tomography skeletal muscle index (SMI), visceral adipose tissue index (VATI), and subcutaneous adipose tissue index (SATI). Pretreatment serum adipocytokine levels, including interleukin 6, insulin, leptin, monocyte chemoattractant protein-1, adiponectin, and resistin, were measured using the multiplex bead-based immunoassays. Cox regression and Kaplan-Meier methods were used for survival analyses. Of the 453 mCRPC patients initially identified, 105 were included in the analysis. High VATI group patients had longer PFS (median, 10 months vs 7 months, P = 0.008) and OS (median, 24 months vs 15 months, P = 0.017), compared with low VATI group patients. SMI and SATI were not significantly associated with PFS or OS. Of the six detected adipocytokines, only leptin was associated with mCRPC prognosis. High leptin group patients had shorter PFS (median, 7 months vs 12 months, P = 0.0018) and OS (median, 17 months vs 22 months, P = 0.042), compared with low leptin group patients. Multivariate analysis showed that a high VATI was an independent protective factor for PFS and OS, while a high leptin level was an independent risk factor for PFS and OS. Therefore, VATI and serum leptin levels could provide important information concerning mCRPC prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: Asia Idioma: En Revista: Asian J Androl Assunto da revista: MEDICINA REPRODUTIVA / UROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans / Male País/Região como assunto: Asia Idioma: En Revista: Asian J Androl Assunto da revista: MEDICINA REPRODUTIVA / UROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China