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Prefabrication-a Vascularized Skin Flap Using an Arteriovenous LoopPrefabricated Flap With Arteriovenous Loop: An Experimental Study in Minipigs.
Liu, Pingping; Wang, Weixin; Ma, Ning; Li, Yangqun; Yang, Zhe; Tang, Yong.
Afiliação
  • Liu P; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
  • Wang W; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
  • Ma N; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
  • Li Y; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
  • Yang Z; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
  • Tang Y; Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing City, China.
J Craniofac Surg ; 34(3): e255-e259, 2023 May 01.
Article em En | MEDLINE | ID: mdl-36727988
BACKGROUND: Arteriovenous loops have a high potency to induce angiogenesis and are promising to solve the problem of scarce implanted pedicle sources and insufficient neovascularization in flap prefabrication. But there is a lack of large animal experiments to support their clinical application. Therefore, we aimed to explore the feasibility of prefabricating large flaps based on arteriovenous loops in pigs. METHODS: Five minipigs were used. In the experimental group, a 10-cm-long ear vein graft was microanastomosed with the saphenous artery and vein to form an arteriovenous loop and implanted under the medial thigh flap. A month later, a 10×10 cm prefabricated flap pedicled with the arteriovenous loop was elevated and sutured in situ. In the control group, a 10×10 cm flap with no vascular pedicle was elevated completely and sutured in situ in the same position. The patency of the arteriovenous loop was evaluated by angiography 30 days after implantation, and the viability of flaps was assessed by macroscopic analysis 10 days after elevation. Three animals received arteriovenous loop flaps unilaterally and no-pedicle flaps unilaterally. Two animals received arteriovenous loop flaps bilaterally. RESULTS: In the experimental group, no thrombi were exhibited in any arteriovenous loop. All 7 prefabricated flaps survived uneventfully. In the control group, 3 flaps were completely necrotic. CONCLUSION: The arteriovenous loops with long interpositional venous grafts can be used as vascular pedicles to prefabricated large area and well-vascularized flaps. This approach can greatly expand the application of flap prefabrication.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retalhos Cirúrgicos / Veias Limite: Animals Idioma: En Revista: J Craniofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Retalhos Cirúrgicos / Veias Limite: Animals Idioma: En Revista: J Craniofac Surg Assunto da revista: ODONTOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China