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Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Krieger, Johannes; Sorrell, Fiona J; Wegener, Ansgar A; Leuthner, Birgitta; Machrouhi-Porcher, Fouzia; Hecht, Martin; Leibrock, Eva M; Müller, Juliane E; Eisert, Jonathan; Hartung, Ingo V; Schlesiger, Sarah.
Afiliação
  • Krieger J; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Sorrell FJ; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Wegener AA; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Leuthner B; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Machrouhi-Porcher F; Site Management Analytics, Merck KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Hecht M; Site Management Analytics, Merck KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Leibrock EM; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Müller JE; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Eisert J; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Hartung IV; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
  • Schlesiger S; Discovery and Development Technologies, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany.
ChemMedChem ; 18(8): e202200615, 2023 04 17.
Article em En | MEDLINE | ID: mdl-36749883
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteína Supressora de Tumor Von Hippel-Lindau Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Proteína Supressora de Tumor Von Hippel-Lindau Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha