New Methodology for Determining Plasma Protein Binding Kinetics Using an Enzyme Reporter Assay Coupling with High-Resolution Mass Spectrometry.

Yan, Zhengyin; Ma, Li; Huang, Julie; Carione, Pasquale; Kenny, Jane R; Hop, Cornelis E C A; Wright, Matthew

Yan, Zhengyin; Ma, Li; Huang, Julie; Carione, Pasquale; Kenny, Jane R; Hop, Cornelis E C A; Wright, Matthew.

Afiliação

Yan Z; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Ma L; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Huang J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Carione P; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Kenny JR; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Hop CECA; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.
Wright M; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California 94080, United States.

Anal Chem ; 95(8): 4086-4094, 2023 02 28.

Article em En | MEDLINE | ID: mdl-36791153

Assuntos

Proteínas Sanguíneas; Fígado; Ligação Proteica; Proteínas Sanguíneas/metabolismo; Fígado/metabolismo; Plasma/metabolismo; Cinética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Sanguíneas / Fígado Tipo de estudo: Prognostic_studies Idioma: En Revista: Anal Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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