Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.

Seedorf, Klaus; Weber, Csaba; Vinson, Cedric; Berger, Sylvie; Vuillard, Laurent-Michel; Kiss, Arpad; Creusot, Stephanie; Broux, Olivier; Geant, Anne; Ilic, Catherine; Lemaitre, Karine; Richard, Johann; Hammoutene, Adel; Mahieux, Julien; Martiny, Virginie; Durand, Didier; Melchiore, Fabien; Nyerges, Miklos; Paradis, Valerie; Provost, Nicolas; Duvivier, Valérie; Delerive, Philippe

Seedorf, Klaus; Weber, Csaba; Vinson, Cedric; Berger, Sylvie; Vuillard, Laurent-Michel; Kiss, Arpad; Creusot, Stephanie; Broux, Olivier; Geant, Anne; Ilic, Catherine; Lemaitre, Karine; Richard, Johann; Hammoutene, Adel; Mahieux, Julien; Martiny, Virginie; Durand, Didier; Melchiore, Fabien; Nyerges, Miklos; Paradis, Valerie; Provost, Nicolas; Duvivier, Valérie; Delerive, Philippe.

Afiliação

Seedorf K; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Weber C; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.
Vinson C; Technologie Servier, 27 Rue Eugène Vignat, 45000 Orleans, France.
Berger S; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Vuillard LM; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Kiss A; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.
Creusot S; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Broux O; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Geant A; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Ilic C; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Lemaitre K; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Richard J; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Hammoutene A; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Mahieux J; Université Paris Cité, Inserm, Centre de Recherche sur l'inflammation, F-75018 Paris, France.
Martiny V; Technologie Servier, 27 Rue Eugène Vignat, 45000 Orleans, France.
Durand D; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Melchiore F; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Nyerges M; Institut de Recherche Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France.
Paradis V; Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary.
Provost N; Département de Pathologie, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, France.
Duvivier V; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.
Delerive P; Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France.

JHEP Rep ; 5(4): 100651, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36866391

Palavras-chave

4-HNE, 4-hydroxynonenal; ARE, antioxidant response element; DIO, diet-induced obesity; GSEA, Gene Set Enrichment Analysis; HEC, hydroxyethyl cellulose; HSCs, Hepatic Stellate Cells; KEAP1, Kelch-like ECH associated protein 1; LPS, lipopolysaccharide; MCDD, methionine- and choline-deficient diet; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH; NASH, non-alcoholic steatohepatitis; NRF2; NRF2, nuclear factor erythroid 2related factor 2; PPI, Protein-protein interaction; PSR, Picrosirius red; ROS, reactive oxygen species; fibrosis; hPBMCs, human peripheral blood mononuclear cells; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: JHEP Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: França

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