Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.
JHEP Rep
; 5(4): 100651, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-36866391
4-HNE, 4-hydroxynonenal; ARE, antioxidant response element; DIO, diet-induced obesity; GSEA, Gene Set Enrichment Analysis; HEC, hydroxyethyl cellulose; HSCs, Hepatic Stellate Cells; KEAP1, Kelch-like ECH associated protein 1; LPS, lipopolysaccharide; MCDD, methionine- and choline-deficient diet; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH; NASH, non-alcoholic steatohepatitis; NRF2; NRF2, nuclear factor erythroid 2related factor 2; PPI, Protein-protein interaction; PSR, Picrosirius red; ROS, reactive oxygen species; fibrosis; hPBMCs, human peripheral blood mononuclear cells; oxidative stress
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
JHEP Rep
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França