Nucleosomal repeat length in active and inactive genes.
FEBS Lett
; 225(1-2): 120-2, 1987 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-3691798
ABSTRACT
Nucleosomal repeat lengths of total chromatin, H4 histone and beta-DR genes have been measured in logarithmically growing HeLa cells. We have detected significant differences in nucleosomal spacing between inactive chromatin and chromatin regions actively engaged in transcription. These differences are also maintained in metaphase chromosomes at times when transcription ceases although a shortening in nucleosomal repeat length is observed in active and inactive chromatin. These observations support a model where DNA-core histone interactions are temporarily altered to allow selective remodelling of chromatin organization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Nucleossomos
/
Antígenos HLA-DR
/
Antígenos HLA-D
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Itália