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AAV9-HGF cooperating with TGF-beta/Smad inhibitor attenuates silicosis fibrosis via inhibiting ferroptosis.
Bao, Rui; Wang, Qiushi; Yu, Mengxue; Zeng, Yaling; Wen, Shengpeng; Liu, Taiyang; Wang, Meng; Li, Yuanyuan; Chang, Sirong; Chi, Hongyang; Ma, Shengchao; Wang, Kai; Yang, Anning; Jiang, Yideng; Liu, Zhihong; Sun, Yue.
Afiliação
  • Bao R; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Wang Q; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Yu M; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Zeng Y; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China.
  • Wen S; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China.
  • Liu T; Fuling Hospital, Chongqing University, 408000 Chongqing, China.
  • Wang M; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Li Y; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Chang S; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Chi H; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China.
  • Ma S; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China.
  • Wang K; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750001, Ningxia, China.
  • Yang A; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Jiang Y; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Liu Z; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
  • Sun Y; School of Public Health and Management, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan 75000, Ningxia, China; NHC KEY Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan 75000, Ningxia, China; Key Laboratory of Environm
Biomed Pharmacother ; 161: 114537, 2023 May.
Article em En | MEDLINE | ID: mdl-36933378
ABSTRACT
Silicosis is a devastating interstitial lung disease characterized by silicon nodules and diffuse pulmonary fibrosis. To date, inefficient therapy is still a challenge of this disease due to its complicated pathogenesis. Hepatocyte growth factor (HGF) which is highly expressed in hepatocyte with anti-fibrotic and anti-apoptotic function was downregulated in silicosis. In addition, the upregulation of transforming growth factor-beta (TGF-ß), another pathological molecular was observed to aggravate the severity and accelerate the progression of silicosis. Here AAV expressed HGF with targeting pulmonary capillaries and SB431542, the inhibitor of TGF-ß signal pathway, were simultaneously adopted to synergistically reduce silicosis fibrosis. In vivo result demonstrated that the cooperation of HGF with SB431542 showed strong anti-fibrosis effects on the silicosis mice via tracheal administration of silica, compared to the separate treatment. The high efficacy was mainly achieved by remarkably by reducing ferroptosis of lung tissue. In our point, the combination of AAV9-HGF with SB431542 provide an alternative to relieve silicosis fibrosis from the perspective of targeting pulmonary capillaries.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silicose / Ferroptose Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silicose / Ferroptose Limite: Animals Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2023 Tipo de documento: Article