Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain.

Tepp, William H; Bradshaw, Marite; Gardner, Alexander P; Kaufman, Rebecca L; Barbieri, Joseph T; Pellett, Sabine

Tepp, William H; Bradshaw, Marite; Gardner, Alexander P; Kaufman, Rebecca L; Barbieri, Joseph T; Pellett, Sabine.

Afiliação

Tepp WH; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
Bradshaw M; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
Gardner AP; Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Kaufman RL; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.
Barbieri JT; Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Pellett S; Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.

Int J Mol Sci ; 24(6)2023 Mar 16.

Article em En | MEDLINE | ID: mdl-36982762

Assuntos

Aminoácidos; Humanos; Ligação Proteica; Domínios Proteicos

Palavras-chave

BoNT; BoNT/A4; SV2C; botulinum neurotoxin; clostridium botulinum; potency; receptor; subtypes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aminoácidos Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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