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Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Shrock, Ellen L; Timms, Richard T; Kula, Tomasz; Mena, Elijah L; West, Anthony P; Guo, Rui; Lee, I-Hsiu; Cohen, Alexander A; McKay, Lindsay G A; Bi, Caihong; Leng, Yumei; Fujimura, Eric; Horns, Felix; Li, Mamie; Wesemann, Duane R; Griffiths, Anthony; Gewurz, Benjamin E; Bjorkman, Pamela J; Elledge, Stephen J.
Afiliação
  • Shrock EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Timms RT; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Kula T; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
  • Mena EL; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
  • West AP; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • Guo R; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Lee IH; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
  • Cohen AA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  • McKay LGA; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Bi C; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Leng Y; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Fujimura E; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
  • Horns F; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
  • Li M; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
  • Wesemann DR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Griffiths A; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
  • Gewurz BE; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Bjorkman PJ; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.
  • Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Science ; 380(6640): eadc9498, 2023 04 07.
Article em En | MEDLINE | ID: mdl-37023193
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epitopos Imunodominantes / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Motivos de Aminoácidos / Interações Hospedeiro-Patógeno / Formação de Anticorpos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epitopos Imunodominantes / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Motivos de Aminoácidos / Interações Hospedeiro-Patógeno / Formação de Anticorpos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos