PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-&#954;B-COX-2-PTGES2 signaling pathway.

Kim, Ji-Eun; Lee, Duk-Shin; Kim, Tae-Hyun; Park, Hana; Kim, Min-Ju; Kang, Tae-Cheon

PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway.

Kim, Ji-Eun; Lee, Duk-Shin; Kim, Tae-Hyun; Park, Hana; Kim, Min-Ju; Kang, Tae-Cheon.

Afiliação

Kim JE; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Lee DS; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Kim TH; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Park H; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Kim MJ; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea.
Kang TC; Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chuncheon, Kangwon-Do, 24252, South Korea. tckang@hallym.ac.kr.

J Neuroinflammation ; 20(1): 99, 2023 Apr 28.

Article em En | MEDLINE | ID: mdl-37118736

Assuntos

NF-kappa B; Neurofibromina 2; Camundongos; Animais; NF-kappa B/metabolismo; Neurofibromina 2/metabolismo; Neurofibromina 2/farmacologia; Ciclo-Oxigenase 2/metabolismo; Quinases Ativadas por p21/metabolismo; Ácido Caínico/toxicidade; Prostaglandina-E Sintases/metabolismo; Fosfatos; Transdução de Sinais; Convulsões/induzido quimicamente; Monoéster Fosfórico Hidrolases/metabolismo; Fosforilação

Palavras-chave

COX-2; IPA-3; Merlin; NF-κB; NF2; PAK1; PLPP/CIN; PTGES2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Neurofibromina 2 Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Coréia do Sul

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